Transforming growth factor beta1 gene polymorphism in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Transforming growth factor beta1 gene polymorphism in rheumatoid arthritis.
OBJECTIVE Rheumatoid arthritis (RA) is a chronic inflammatory disease and synovial cells, antigen presenting cells, lymphocytes, and their cytokines might be associated with the disease. Transforming growth factor beta1 (TGFbeta1) has been reported to have important roles in unresolved inflammation, immune suppression, fibrosing processes, and angiogenesis. TGFbeta1 is highly expressed in joint...
متن کاملTransforming growth factor-beta1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis.
OBJECTIVES Part of the deleterious effects of systemic inflammation on the cardiovascular system of patients with RA may be exerted via increased propensity to hypertension. IL-6 and TGF-beta1 are important regulators of the inflammatory response. In some, but not all, studies, IL6 -174G/C (rs1800795) and TGFB1 869T/C (rs1982073) gene polymorphisms have been associated with hypertension in the ...
متن کاملA common polymorphism of the transforming growth factor-beta1 gene and coronary artery disease.
Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine involved in many physiological and pathological processes. Its actions are complex and in vitro experiments and clinical findings suggest that under different circumstances it may have opposing biological effects [1]. There are in vitro experimental data indicating that it may be both anti-atherogenic [2] and proatherogenic [3...
متن کاملAssociation of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy.
BACKGROUND A recent study showed that transforming growth factor-beta1 (TGF-beta1) induces amyloid-beta deposition in cerebral blood vessels and meninges of a transgenic mouse model of Alzheimer's disease (AD), and that TGF-beta1 mRNA levels are correlated with cerebral amyloid angiopathy (CAA) in human AD brains. A T/C polymorphism at codon 10 in exon 1 of the TGF-beta1 gene has been reported ...
متن کاملAssociation of polymorphism in the transforming growth factor {beta}1 gene with disease outcome and mortality in rheumatoid arthritis.
OBJECTIVE To investigate whether polymorphism in the transforming growth factor beta1 (TGFbeta1) gene is associated with disease outcome in rheumatoid arthritis. METHODS 208 patients with established rheumatoid arthritis were genotyped for the TGFbeta1 T869C polymorphism using an amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method. Disease severity was assesse...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2002
ISSN: 0003-4967
DOI: 10.1136/ard.61.9.826